Masami HASEGAWA
Professor Emeritus
Personal
Homepage:		 http://www.evol.ism.ac.jp/
Date of Birth: March, 1944
Education: Bachelor of Science, Department of Physics, Tohoku Univ., 1966
Master of Science, Graduate School of Science, Nagoya Univ., 1968
Doctor of Science, Graduate School of Science, Nagoya Univ., 1970
Degree: Doctor of Science, Univ. of Tokyo, 1973, Title of Doctoral Thesis: Study of the Hydrogen Bonding by the Valence Bond and Molecular Orbital Methods.
Employment: 1970-1975 Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo (Assistant Professor)
1975-present Institute of Statistical Mathematics
Research Scientist 1975-1977
Chief Research Scientist 1977-1985
Associate Professor 1985-1986
Professor 1986-2007
2005-2007 Department of Statistical Modeling;
Director, Prediction and Knowledge Discovery Research Center
1988-1999 Department of Statistical Sciences, Graduate University for Advanced Studies (Professor)
1999-2006 Department of Biosystems Science, Graduate University for Advanced Studies (Professor)
1999-2006 Department of Biological Sciences, University of Tokyo(Professor)
2007-present, Professor Emeritus, ISM.
2008-2014 present Graph Modeling Group, Prediction and Knowledge Discovery Research Center (Adjunct Professor)
Honors &
Awards: 		1999 Kihara Prize from the Genetics Society of Japan
2003 Japan Statistical Society Prize
2005 Kimura Prize, Evolution Society of Japan
Research
Fields:		 Statistical genetics, Molecular evolution
Research
Themes:		 Statistical methods for inferring molecular phylogenies by using DNA and protein sequences

Selected Papers
(1) M. Hasegawa and H. Noda (1975): Distribution of hydrogen bond angles in molecular crystals, Nature, 254, p.212.
(2) M. Hasegawa, H. Kishino, and T. Yano (1985): Dating of the human-ape splitting by a molecular clock of mitochondrial DNA, J. Mol. Evol., 22 , 160-174.
(3) M. Hasegawa and H. Kishino (1989): Confidence limits on the maximum-l ikelihood estimate of the hominoid tree from mitochondrial-DNA sequences , Evolution, 43 , 672-677.
(4) H. Kishino and M. Hasegawa (1989): Evaluation of the maximum likelihood estimate of the evolutionary tree topologies from DNA sequence data, and the branching order in Hominoidea, J. Mol. Evol., 29, 170-179.
(5) N. Iwabe, K. Kuma, M. Hasegawa, S. Osawa, and T. Miyata (1989): Evolutionary relationship of archaebacteria, eubacteria, and eukaryotes inferred from phylogenetic trees of duplicated genes, Proc. Natl. Acad. Sci. USA, 86 , 9355-9359.
(6) H. Kishino, T. Miyata, and M. Hasegawa (1990): Maximum likelihood inference of protein phylogeny and the origin of chloroplasts, J. Mol. Evol., 30, 151-160.
(7) M. Hasegawa, Y. Cao, J. Adachi, and T. Yano (1992): Rodent polyphyly?, Nature, 355, p.595.
(8) M. Hasegawa and T. Hashimoto (1993): Ribosomal RNA trees misleading?, Nature, 361, p.23.
(9) M. Hasegawa, A. Di Rienzo, T.D. Kocher, and A.C. Wilson (1993): Toward a more accurate time scale for the human mitochondrial DNA tree, J. Mol. Evol., 37, 347-354.
(10) M. Hasegawa and H. Kishino (1994): Accuracies of the simple methods for estimating the bootstrap probability of a maximum likelihood tree, Mol. Biol. Evol., 11, 142-145.
(11) J. Adachi and M. Hasegawa (1995): Improved dating of the human-chimpanzee separation in the mitochondrial DNA tree, J. Mol. Evol., 40, 622-628.
(12) J. Adachi and M. Hasegawa (1996): Model of amino acid substitution in proteins encoded by mitochondrial DNA, J. Mol. Evol., 42, 459-468.
(13) M. Hasegawa and W.M. Fitch (1996): Dating the cenancestor of organis ms, Science, 274, p.1750.
(14) M. Hasegawa, J. Adachi, and M.C. Milinkovitch (1997) Novel phylogeny of whales supported by total molecular evidence, J. Mol. Evol., 44S, 117-120.
(15) D. Penny and M. Hasegawa (1997): The platypus put in its place, Nature, 387, 549-550.
(16) W. Martin, B. Stobe, V. Goremykin, S. Hansmann, M. Hasegawa, and K.V. Kowallik (1998): Gene transfer to the nucleus and the evolution of chloroplasts, Nature, 393, 162-165．
(17) P. Waddell, N. Okada, and M. Hasegawa (1999): Towards resolving the interordinal relationships of placental mammals, System. Biol., 48, 1-5.
(18) H. Shimodaira and M. Hasegawa (1999): Multiple comparisons of log-likelihoods with applications to phylogenetic inference, Mol. Biol. Evol., 16, 1114-1116.
(19) M. Hasegawa, J.L. Thorne, and H. Kishino (2003): Time scale of eutherian evolution estimated without assuming a constant rate of molecular evolution, Genes Genet. Syst., 78, 267-283.
(20) N. Arisue, M. Hasegawa, and T. Hashimoto (2005): Root of the eukaryote tree as inferred from combined maximum likelihood analyses of multiple molecular sequence data. Mol. Biol. Evol., 22, 409-420.
(21) H. Nishihara, M. Hasegawa, and N. Okada (2006): Pegasoferae, an unexpected mammalian clade revealed by tracking ancient retroposon insertions. Proc. Natl. Acad. Sci. USA, 103, 9929-9934.
(22) H. Nishihara, N. Okada, and M. Hasegawa (2007): Rooting the eutherian tree: the power and pitfalls of phylogenomics, Genome Biology, 8, R199.

Selected Publications
(1) M. Hasegawa and H. Kishino (1996):Molecular Phylogenetics (in Japanese), Iwanami Publ., Tokyo.
(2) M. Hasegawa (1992):What Genes Tell about Your Ancestors (in Japanese), Asunaro Shobou, Tokyo.
(3) M. Hasegawa (1991):Evolutionary History of Humans Inscribed on the DNA (in Japanese), Iwanami Publ., Tokyo.
(4) M. Hasegawa (1984): Origin and Evolution of Humans as Inferred from DNA (in Japanese), Kaimeisha Publ., Tokyo.

Membership of Academic Societies
Society for Molecular Biology and Evolution, International Society of Molecular Evolution, Japan Evolution Society, Japan Statistical Society, Genetics Society of Japan, Molecular Biology Society of Japan

Teaching at The Graduate University for Advanced Studies
Shcool of Advanced Sciences, Department of Biosystems Science

Professional Services
2007-: Professor of School of Life Sciences, Fudan University
2007-: Adjunct Professor of National Institute of Genetics

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