曹   纓 (Ying CAO) 助教

【所   属】

モデリング研究系 グラフ構造モデリンググループ
予測発見戦略研究センター ゲノム解析グループ

 

【連 絡 先】

E-mail : cao

 

【職   歴】

1998 年 4 月  

日本学術振興会外国人特別研究員

2000 年 4 月  

統計数理研究所COE研究員

2003 年 1 月  

統計数理研究所予測制御研究系助手

2003 年 4 月  

総合研究大学院大学先導科学研究科生命体科学専攻助手(併任)

2005 年 4 月  

統計数理研究所モデリング研究系助手、予測発見戦略研究センター(兼務)

2007 年 4 月

2007 年 4 月  

統計数理研究所モデリング研究系助教、予測発見戦略研究センター(兼務)

総合研究大学院大学先導科学研究科生命体科学専攻助教(併任)

【学   位】

理学博士(東京工業大学,1998年)
"Molecular Phylogeny and Evolution of Vertebrates"

【専門分野】

分子系統学、統計遺伝学

【研究テーマ】

「分子系統樹及び分岐年代推定における研究」「最尤系統樹の探索法」「分子系統学分野におけるデータ解析」
(陸上脊椎動物の起源/大陸の移動と哺乳類の進化/羊膜類の系統進化)

【論   文】

(1) Hasegawa, M., Cao, Y., Adachi, J. and Yano T. (1992): Rodent polyphyly? Nature, 355, 595-595.
(2) Adachi, J., Cao, Y. and Hasegawa, M. (1993): Tempo and mode of mitochondrial DNA evolution in vertebrates at the amino acid sequence level: rapid evolution in warm-blooded vertebrates, J. Mol. Evol., 36, 270-281.
(3) Cao, Y., Adachi, J., Janke, A., Paabo, S. and Hasegawa, M. (1994): Phylogenetic relationships among eutherian orders estimated from inferred sequences of mitochondrial proteins, J. Mol. Evol., 39, 519-527.
(4) Cao, Y., Adachi, J., Yano, T. and Hasegawa, M. (1994): Phylogenetic place of guinea pigs: no support of the rodent polyphyly hypothesis from maximum likelihood analyses of multiple protein sequences, Mol. Biol. Evol., 11, 593-604.
(5) Cao, Y., Adachi, J. and Hasegawa, M. (1994): Eutherian phylogeny as inferred from mitochondrial DNA sequence data, Jpn. J. Genet., 69, 455-472.

(6) Shirakura T., Hashimoto, T., Nakamura, Y., Kamaishi, T., Cao, Y., Adachi, J., Hasegawa, M., Yamamoto, A. and Goto, N. (1994): Phylogenetic place of a mitochondria-lacking protozoan, Entamoeba histolytica, inferred from amino acid sequences of elongation factor 2. Jpn. J. Genet., 69, 119-135.
(7) Cao, Y., Okada, N. and Hasegawa, M. (1997): Phylogenetic position of guinea-pigs revisited, Mol. Biol. Evol., 14, 461-464.
(8) Ishida, K., Cao, Y., Hasegawa, M., Okada, N. and Hara, Y. (1997): The origin of chlorarachniophyte plastids inferred from EF-Tu amino acid sequence phylogeny, J. Mol. Evol., 45, 682-687.
(9) Cao, Y., Adachi, J. and Hasegawa, M. (1998): Comment on the quartet puzzling method for finding maximum-likelihood tree topologies. Mol. Biol. Evol., 15, 87-89.
(10) Cao, Y., Janke, A., Waddell, P. J., Westerman, M., Takenaka, O., Murata, S., Okada, N., Paabo, S. and Hasegawa, M. (1998): Conflict among individual mitochondrial proteins in resolving the phylogeny of eutherian orders, J. Mol. Evol., 47, 307-322.
(11) Cao, Y., Waddell P. J., Okada N. and Hasegawa M. (1998): The complete mitochondrial DNA sequence of the shark Mustelus manazo: Resolving vertebrate phylogeny with mitochondrial genome sequences when all known methods fail completely, Mol. Biol. Evol., 15, 1637-1646.
(12) Zardoya, R., Cao, Y., Hasegawa, M. and Meyer, A. (1998): Searching for the closest living relative(s) of tetrapods through evolutionary analyses of mitochondrial and nuclear data, Mol. Biol. Evol., 15, 506-517.
(13) Hasegawa, M., Cao, Y. and Yang, Z. (1998): Preponderance of slightly deleterious polymorphism in mitochondrial DNA: Nonsynonymous/synonymous rate ratio is much higher within species than between species, Mol. Biol. Evol., 15, 1499-1505.
(14) Shimodaira, H. and Cao, Y. (1998): A graphical technique for model selection diagnosis, Research Memorandum Inst Statist Math., 680, 1-24.

(15) 曹纓、長谷川政美 (1998): 最尤系統樹の探索法. 統計数理, 46, 401-409.
(16)
長谷川政美、曹纓 (1998): 哺乳動物の歴史. 高畑尚之(編)「生命体システムの由来と未来」, 総合研究大学院大学, 94-105

(17) Cao, Y., Kim, K. S., Ha, J. H. and Hasegawa, M. (1999): Model dependence of the phylogenetic inference: Relationship among carnivores, perissodactyls and cetartiodactyls as inferred from mitochondrial genome sequences, Genes Genet. Syst., 74, 211-217.
(18) Waddell, P., Cao, Y., Hauf, J. and Hasegawa, M. (1999): Using novel phylogenetic methods to evaluate mammalian mtDNA, including amino acid-invariant sites-LogDet plus site stripping, to detect internal conflicts in the data, with special reference to the positions of hedgehog, armadillo, and elephant, System. Biol., 48, 31-53.
(19) Waddell, P., Cao, Y., Hasegawa, M. and Mindell, D.P. (1999): Assessing the Cretaceous superordinal divergence times within birds and placental mammals by using whole mitochondrial protein sequences and an extended statistical framework, System. Biol., 48, 119-137.
(20) Tohyama, Y., Kasama-Yoshida, H., Sakuma, M., Kobayashi, Y., Cao, Y., Hasegawa, M., Kojima, H., Tamai, Y., Tanokura, M. and Kurihara, T. (1999): Gene structure and amino acid sequence of Latimeria chalumnae (coelacanth) myelin DM20: Phylogenetic relation of the fish, Neurochemica Reserch, 24, 867-873.

(21)
長谷川政美、曹纓 (1999): 大陸の移動と哺乳類の進化, 科学, 69, 440-448.
(22) Cao, Y., Sorenson, M. D., Kumazawa, Y., Mindell, D. P. and Hasegawa, M. (2000): Phylogenetic position of turtles among amniotes: evidence from mitochondrial and nuclear genes, Gene, 259, 139-148.
(23) Cao, Y., Fujiwara, M., Nikaido, M., Okada, N. and Hasegawa, M. (2000): Interordinal relationships and timescale of eutherian evolution as inferred from mitochondrial genome data, Gene, 259, 149-158.
(24) Nikaido, M., Harada, M., Cao, Y., Hasegawa, M. and Okada, N. (2000): Monophyletic origin of the order Chiroptera and its phylogenetic position among Mammalia inferred from the complete mitochondrial DNA sequence of a Japanese megabat; Ryukyu flying fox (Pteropus dasymallus), J. Mol. Evol., 51, 318-328.
(25) Onuma, M., Cao, Y., Hasegawa, M. and Kusakabe, S. (2000): A close relationship of Chiroptera with Eulipotyphla (core Insectivora) suggested by four mitochondrial gene, Zool, 17, 1327-1332.
(26) Tohyama, Y., Ichimiya, T., Kasama-Yoshida, H., Cao, Y., Hasegawa, M., Kojima, H., Tamai, Y. and Kurihara, T. (2000): Phylogenetic relation of lungfish indicated by the amino acid sequence of myelin DM20, Mol Brain Res, 80, 256-259.
(27) Nikaido, M., Matsuno, F., Hamilton, H., Brownell, R. L. Jr., Cao, Y., Wang, D., Zhou, Z., Shedlock, A. M., Fordyce, R. E., Hasegawa, M. and Okada, N. (2001): Retroposon analysis of major cetacen lineages: the monophyly of toothed whales and the paraphyly of river dolphins, Proc. Natl. Acad. Sci. USA, 98, 7384-7389.
(28) Nikaido, M., Kawai, K., Cao, Y., Harada, M., Tomita, S., Okada, N. and Hasegawa, M. (2001): Maximum likelihood analysis of the complete mitochondrial genomes of eutherians and a reevaluation of the phylogeny of bats and insectivores, J. Mol. Evol., 53, 508-516.
(29) Pupko, T., Huchon, D., Cao, Y., Okada, N. and Hasegawa, M. (2002): Combining multiple data Sets in a likelihood analysis: Which Models are the Best? Mol. Biol. Evol., 19(12), 2294-2307.

(30) 曹纓、長谷川政美 (2002): 分子系統樹推定におけるモデルのミススペシフィケーション―脊椎動物の系統進化を例として―, 統計数理, 50, 69-85.
(31) Nikaido, M., Cao, Y., Harada, M., Okada, N. and Hasegawa, M. (2003): Mitochondrial phylogeny of hedgehogs and monophyly of Eulipotyphla, Mol. Phylogenet. Evol., 28, 276-284.
(32)
Murata, Y., Nikaido, M., Sasaki, T., Cao, Y., Fukumoto, Y., Hasegawa, M. and Okada, N. (2003): Afrotherian phylogeny as inferred from complete mitochondrial genomes, Mol. Phylogenet. Evol., 28, 253-260.
(33)
Nikaido, M., Cao, Y., Okada, N. and Hasegawa, M. (2003): The phylogenetic relationships of insectivores with special reference to the lesser hedgehog tenrec as inferred from the complete sequence of their mitochondrial genome, Genes Genet. Syst., 78, 107-112.

(34) Sasaki, T., Nikaido, M., Hamilton, H., Goto, M., Kato, H., Kanda, N., Pastene, L., Cao, Y., Fordyce, R., Hasegawa, M. and Okada, N. (2005): Mitochondrial phylogenetics and evolution of mysticete whales, System. Biol., 54(1), 77-90.
(35)
Li, Z., Liu, Q., Song, M., Zheng, Y., Nan, P., Cao, Y., Chen, G., Li, Y.and Zhong, Y. (2005): Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes, BioSystems, 82, 226-234.
(36)
Zhang, Y., Zheng, N., Hao, P., Cao, Y. and Zhong Y. (2005): A molecular docking model of SARS-CoV S1 protein in complex with its receptor, human ACE2, Computational Biology and Chemistry, 29, 254-257.
(37)
Watanabe, M., Nikaido, M., Tsuda, T.T., Kobayashi, T., Mindell, D., Cao, Y., Okada, N. and Hasegawa, M. (2006): New candidate species most closely related to penguins, Gene, 378, 65-73.
(38)
Sasaki, T., Nikaido M., Wada S., Yamada T.K., Cao, Y., Hasegawa, M. and Okada, N. (2006): Balaenoptera omurai is a newly discovered baleen whale that represents an ancient evolutionary lineage, Mol. Phylogenet. Evol., 41, 40-52.
(39) Zhang, Y., Zheng, N., Nan, P., Cao, Y., Hasegawa, M. and Zhong, Y. (2007): Computational simulation of interactions between SARS coronavirus spike mutants and host species-specific receptors, Computational Biology and Chemistry, 31, 134-137.

【著   書】

長谷川政美等著(2005: 「听基因講祖先的故事」 (曹纓、鍾陽編), 上海科技教育出版社

【学   会】

International Society for Molecular Biology and Evolution, 日本遺伝学会, 日本進化学会, 日本分子生物学会, 生き物文化誌学会

【受 賞 歴】

井上科学振興財団 第17回井上研究奨励賞 2001年2月「脊椎動物の分子進化とその系統関係の解明」

【所外における活動】

Systematics Biology, Editorial Board Member (2002年−2005年)