Shuhei MANO Associate Professor, Mathematical Statistics Group, Department of Mathematical Analysis and Statistical Inference

E-mail: smano Personal Homepage: http://www.ism.ac.jp/~smano/ Education: Doctor of Science, Graduate School of Science, Osaka Univ., 1999 Degree: Doctor of Science, Osaka Univ., 1999, Title of Doctoral Thesis: Thermodynamics of Extremal Black Holes in String Theory. Doctor of Science, Graduate Univ. for Advanced Studies, 2008, Title of Doctoral Thesis: Stochastic Models in Population Genetics. Employment: 2001 Researcher, National Institute of Genetics 2001-2004 Researcher, National Institute of Advanced Industrial Science and Technology 2004-2010 Nagoya City Univ. (2004 Assistant Professor; 2005-2010 Associate Professor) 2010- Associate Professor, The Institute of Statistical Mathematics Research Fields: Mathematical Genetics, Statistical Genetics Research Themes: Stochastic Models in Population Genetics

Selected Papers
(1) Mano, S., Yasuda, N., Katoh, T., Tounai, K., Inoko, H., Imanishi, T., Tamiya, G., Gojobori, T. (2004): Notes on the maximum likelihood estimation of haplotype frequencies, Annals of Human Genetics 68, 257-264.
(2) Mano, S. (2005): Random genetic drift and gamete frequency, Genetics 171, 2043-2050.
(3) Tanaka, Y., Kurbanov, F., Mano, S., Orito, E., Vargas, V., Esteban, J.I., Yuen, M-F., Lai, C-L., Kramvis, A., Kew, M.C., Smuts, H.E.m Netesov, S.V., Alter, H.J., Mizokami, M. (2006): Molecular tracing of the grobal hepatits C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality, Gastroenterology 130, 703-714.
(4) Mano, S. (2007): Evolution of linkage disequilibrium of the founders in exponentially growing populations, Theoretical Population Biology 71, 95-108.
(5) Zeng, K., Mano, S., Shi, S., Wu, C-I. (2007): Comparisons of site- and haplotype-frequency methods for detecting positive selection, Molecular Biology and Evolution 24, 1562-1574.
(6) Mano, S., Innan, H. (2008): The evolutionary rate of duplicated genes under concerted evolution, Getetics 180, 493-505.
(7) Mano, S. (2009): Duality, ancestral and diffusion processes in models with selection, Theoretical Population Biology 75, 164-175.
(8) Mano, S., Endo, T.A., Oka, A., Ozawa, A., Gojobori, T., Inoko, H. (2009): Detecting linkage between a trait and a marker in a random mating population without pedigree record, PLoS One 4, e4956.
(9) Osada, N., Mano, S,., Gojobori, J. (2009): Quantifying dominance and deleterious effect on human disease genes, Proceedings of the National Academy of Science, USA 106, 841-846.
(10) Nakagome, S., Takeyama, Y., Mano, S., Sakisaka, S., Matsui, T., Kawamura, S., Oota, H. (2010): Population-specific susceptibility to Crohn's disease and ulcerative colitis; Dominant and recessive relative risks in the Japanese population, Annals of Human Genetics 74, 126-136.

Membership of Academic Societies
Biometric Society of Japan, Genetics Society of Japan, Japan Society for Mathematical Biology, Japan Society of Evolutionary Studies, Japan Society of Human Genetics, Japan Statistical Society

Professional Services
2010- : Editorial Board, Journal of Theoretical Biology

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