(Received April 7, 1997; revised May 18, 1998)
Abstract. We discuss conditions under which an equally weighted design is D-optimal. The concept of a model being maximally invariant with respect to a set is introduced and is shown to be useful in this work. Several illustrative examples are given, including two biomedical applications using compartmental and segmented models.
Key words and phrases: D-optimum design, equivalence theorem, G-optimum design, information matrix.
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